• The underlying mechanisms of how progesterone prolongs

  2021-02-03

  

  The underlying mechanisms of how progesterone prolongs pregnancy, although not completely understood, are thought to have to do with reduction in uterine contractility, antimicrobial protein up-regulation, immunosuppression, and inflammatory inhibition. Specific to preterm PROM, progesterone has bee

• The presence of a vicious

  2021-02-03

  

  The presence of a “vicious cycle” established between tumor proliferation and paratumor osteolysis plays a crucial role in the development of primary bone tumors [53]. Cancer cells produce soluble factors that activate directly or indirectly via osteoblasts, osteoclast differentiation and maturation

• Introduction Enzymes have higher selectivity specificity and

  2021-02-03

  

  Introduction Enzymes have higher selectivity, specificity and efficiency than chemical catalysts. Due to their properties and their green chemistry, biocatalysts are widely used in food, textile and pharmaceutical industry [1], [2]. A high efficient biocatalyst for industrial applications must be s

• Accordingly we prepared three compounds and as shown in

  2021-02-03

  

  Accordingly, we prepared three compounds (, , and ) as shown in . Condensation of commercially available BI6727 with glycine methyl ester gave amide . A Friedel–Crafts reaction between compound and 4-methyl valeryl chloride in the presence of aluminum chloride mainly produced undesired compound

• Atractyloside Dipotassium Salt Obviously there are some limi

  2021-02-03

  

  Obviously, there are some limitations in our study; due to sample constraints, we had to focus our efforts on one specific T cell epitope from one candidate autoantigen. Optimally, we could have studied several different peptides in parallel. Additionally, all RA patients included in the study have

• Imeglimin br STAR Methods br Microenvironmental niches for n

  2021-02-03

  

  STAR★Methods Microenvironmental niches for naïve and activated B cells Secondary lymphoid organs, such as the spleen and lymph nodes, are structurally and functionally compartmentalized to provide a set of microenvironmental niches that support the survival of resting B cells, as well as the a

• What are the molecular signals that

  2021-02-03

  

  What are the molecular signals that guide Tfh cells as they navigate around the lymph node in the course of the immune response? It was recently reported that Tfh cells inside GCs have high expression of SIPR2, which acts to repel them from the S1P-rich lymph in the SCS and promote their retention i

• br Results br Discussion In this paper we present insights

  2021-02-02

  

  Results Discussion In this paper we present insights into the observed specificities of inhibitors targeting the ubiquitin-activating and related E1 N1-Methyl-ATP via crystal structures of the specific NEDD8-E1 inhibitor MLN4924, the dual NEDD8/Ub E1 inhibitor ABPA3, and the selective Ub-E1 in

• It was hypothesized that if modafinil acts primarily

  2021-02-02

  

  It was hypothesized that if modafinil acts primarily via a noradrenergic mechanism, Dbh −/− mice should be non-responsive since they completely lack NE. In contrast, if modafinil acts mainly through DA systems, these mice should be hypersensitive. Modafinil was tested in Dbh −/− mice using both loco

• br Concluding remark br Acknowledgements br

  2021-02-02

  

  Concluding remark Acknowledgements Detection and repair of the numerous, and potentially lethal, DNA lesions arising in human prostanoid receptors daily is largely mediated by an efficient system collectively termed the DNA-damage response (DDR). Paradoxically, DNA-repair processes within c

• br Introduction DNA ligation is

  2021-02-02

  

  Introduction DNA ligation is required during DNA replication and to complete almost all DNA repair events. In human cells, the DNA ligases encoded by three LIG genes are responsible for joining interruptions in the phosphodiester backbone [1]. These enzymes have distinct but overlapping functions

• In a recent study Tomkins et al analyzed

  2021-02-02

  

  In a recent study, Tomkins et al. [7] analyzed the protein-protein interaction network of ROCO proteins. Based on a database analysis, and only taking into account interactions reported in at least two peer-reviewed papers and/or confirmed by two different methods, 113 interactors were revealed for

• Recently a sandwich cultured hepatocyte

  2021-02-02

  

  Recently, a sandwich-cultured hepatocyte model has been proved to be a valuable in vitro system that maintains specific hepatic cytomorphology and function relevant to drug metabolism, disposition and toxicity, and thus, closely resembles the in vivo setting. This hepatocyte model was recognized as

• The early serologic response of infants

  2021-02-02

  

  The early serologic response of infants to infection with HIV-1 is obscured by the presence of transplacentally acquired maternal HIV antibody. However, the HIV LY-411575 produced in vitro by peripheral blood from infants has been studied (Pollack et al., 1993) and it has been shown that neonatal i

• br Results br Discussion br Experimental Procedures br Autho

  2021-02-02

  

  Results Discussion Experimental Procedures Author Contributions Acknowledgments Introduction Excitatory synaptic transmission within the brain is largely mediated by ionotropic glutamate receptors. At glutamatergic synapses, α-amino-3-hydroxy-5-methylisoxazole-4-proprionic Ganetesp

16062 records 735/1071 page Previous Next First page 上5页 731732733734735 下5页 Last page